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Kidney Cancer Journal 79 temic agents for RCC. The now well-known immune modulatory and antigen presenting properties of SAbR, which has not been elaborated and is beyond the scope of this review, may synergize with the approved and upcoming immunotherapies for RCC. While much is known about the local control, the impact of SAbR on PFS and eventually on extending patient survival is not known yet and careful design of prospective trials is clearly needed in this setting. With greater application of SAbR, the focus needs to be maintained on careful patient selection for the technique to be safely and effectively implemented and outcomes optimized, including long-term survival. References 1. Boike TP, Lotan Y, Cho LC, Brindle J, DeRose P, Xie XJ, Yan J, Foster R, Pistenmaa D, Perkins A, Cooley S, Timmerman R. Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate risk prostate cancer. J Clin Oncol. 2011;29(15):2020-6. 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Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol. 2007;25(8):947-52. 6. Berber B, Sanabria JR, Braun K, Yao M, Ellis RJ, Kunos CA, Sohn J, Machtay M, Teh BS, Huang Z, Mayr NA, Lo SS. Emerging role of stereotactic body radiotherapy in the treatment of pancreatic cancer. Expert Review of Anticancer Therapy. 2013;13(4):481-7. 7. Tao C, Yang LX. Improved radiotherapy for primary and secondary liver cancer: stereotactic body radiation therapy. Anticancer Research. 2012;32(2):649-55. 8. Kwon JH, Bae SH, Kim JY, Choi BO, Jang HS, Jang JW, Choi JY, Yoon SK, Chung KW. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer. BMC Cancer. 2010;10:475. doi: 10.1186/1471-2407-10-475. PubMed PMID: 20813065; PMCID: 2940809. 9. 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